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Critical Solutions for Your Critical Environment

Contact us to start a project, become an industry partner, or learn more about the only cleanroom provider that puts client experience first.

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Dry Rooms

Learn more about our dry room expertise.

Dry Rooms

Advanced Dry Rooms Built for Operational Readiness

Dry rooms for semiconductor, battery cell and advanced manufacturing require far more than low humidity. These are highly controlled production environments where airborne particulate levels, electrostatic discharge, temperature, pressure, moisture and contamination can directly affect product quality, equipment performance and production yield. CleanSpace designs and delivers ISO 5 and ISO 4 environments engineered around the process, equipment, material flow and exact environmental conditions required for reliable manufacturing.

Our teams bring specialized experience in lithium ion battery production, including electrode manufacturing, cell assembly and the safe segregation of cathode and anode powders. We account for cross contamination risk, powder migration, combustible dust, hazardous material handling, personnel and material flows, cleanability and maintainability from the earliest stages of design. Antistatic materials, conductive flooring, grounding and bonding, ESD controls and carefully selected architectural finishes are integrated into the facility design to protect sensitive products, processes and equipment.

The mechanical systems behind a dry room determine whether it can consistently perform. CleanSpace engineers desiccant dehumidification, high performance air handling, HEPA and ULPA filtration, temperature and humidity control, pressure cascades, process exhaust, heat recovery and environmental monitoring as one coordinated system. Airflow modeling, load analysis and equipment integration help us establish the correct room conditions while balancing energy use, maintainability, redundancy and future production demands.

As a vertically integrated modern design builder, CleanSpace provides one accountable source from initial planning, Basis of Design and digital modeling through engineering, preconstruction, manufacturing, construction, installation, commissioning and qualification. Our teams coordinate the architecture, mechanical systems, controls, utilities and process equipment before work reaches the field, reducing interface risk and creating greater certainty around cost, schedule and performance.

The goal is not simply to construct a classified space. It is to deliver a manufacturing environment that is ready to operate, capable of maintaining its specified conditions and designed to support production from day one. CleanSpace brings design, engineering, construction and compliance together to move advanced manufacturing facilities from concept to operational readiness with greater control and certainty.

What ISO Classification Does Not Define

ISO classification establishes allowable airborne particle concentrations. It does not independently determine:

  • Air changes per hour
  • Temperature or relative humidity
  • Dew point
  • Room pressure
  • HEPA or ULPA coverage
  • ESD and antistatic requirements
  • Chemical contamination limits
  • Process exhaust requirements
  • Personnel gowning protocols

For battery dry rooms, semiconductor facilities and other advanced manufacturing environments, these conditions must be engineered around the product and process. A room may require ISO 5 particulate control while also maintaining an extremely low dew point, anti-static construction, conductive flooring, grounding and bonding, pressure cascades, segregated cathode and anode operations, specialized exhaust and continuous environmental monitoring. CleanSpace’s internal in-house teams have the expertise to ensure the design and engineering are in alignment with manufacturing and operations requires.  

ISO Cleanroom Classification Requirements

ISO Class Maximum particles ≥0.1 µm per m³ Maximum particles ≥0.5 µm per m³ Typical applications Typical environmental controls
ISO 1 10 Not specified Extreme nanoscale research and highly specialized semiconductor processes Unidirectional airflow, ULPA filtration, extremely strict material and personnel controls
ISO 2 100 4 Advanced semiconductor fabrication, nanotechnology and critical microelectronics ULPA filtration, continuous particle monitoring, precise airflow and vibration control
ISO 3 1,000 35 Semiconductor wafer processing, photolithography and advanced optical manufacturing Unidirectional airflow, ULPA filtration, tightly controlled temperature, humidity and pressure
ISO 4 10,000 352 Advanced semiconductor processing, battery cell production and sensitive component assembly High coverage HEPA or ULPA filtration, ESD controls, controlled airflow and continuous monitoring
ISO 5 100,000 3,520 Battery cell assembly, semiconductor production, aseptic processing and critical manufacturing zones HEPA or ULPA filtration, controlled pressure cascades, temperature, humidity and contamination controls
ISO 6 1,000,000 35,200 Precision electronics, battery manufacturing and controlled component assembly HEPA filtration, controlled personnel and material flow, environmental monitoring and ESD protection
ISO 7 Not specified 352,000 Pharmaceutical processing, medical devices, electronics and advanced manufacturing support areas HEPA filtration, positive or negative pressure, gowning controls and cleanable finishes
ISO 8 Not specified 3,520,000 General manufacturing, packaging, material preparation and controlled support spaces Filtered air, defined pressure relationships, controlled access and cleanable construction
ISO 9 Not specified 35,200,000 Controlled production or warehouse environments requiring cleaner conditions than ordinary indoor air General filtration, housekeeping controls and basic environmental monitoring

Our certifications

Good Manufacturing Practice
Isnetworld Member Contractor
ISO
UL
FM approved
ASTM International
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CleanSpace worked with Metagenomi to master plan, design, and develop our cGMP clinical process suite. They were an exemplary partner from start to finish, displaying a high level of professionalism, thoughtfulness, and flexibility.

Dry Rooms
Jian Irish
President & COO of Metagenomi

The Modern Design Build Process

Our team accelerates the design to installation process and is what enables CleanSpace to offer timeline and budget guarantees.

Norwood, MA

PCT Sterile Filling and Operation

Square Footage

27,000

Special details

Phase 1 & 2 Expansion of vaccine plant.

Project Hightlights

  • Modular wall and ceiling panels, cleanroom doors, high-speed roll-up doors.
  • Filling line expansion, fast-track project.
Hatboro, PA

Process Systems

Square Footage

2,000

Special details

Medical tubing cleanroom suite.

Project Hightlights

  • ISO 7 Single-Use Product Assembly Room.
  • Gowning rooms, doors, interlocks.
  • Innovative Control Systems.
Emeryville, CA

Gene Therapy Pilot Plant

Square Footage

Not specified

Special details

New cGMP flexible clinical process suite for early clinical manufacturing.

Project Hightlights

  • Supports nuclease(s), mRNA-LNP, AAV, and Cell Therapy.
  • Three core gene therapy suites + two shared drug product filling operations.
  • Quality Control laboratories for bioassay, PCR, vector, and Microbiology.
Houston, TX

cGMP Manufacturing Facility

Square Footage

23,000

Special details

CleanSpace successfully delivered a 22,000 SF state-of-the-art facility, featuring 2,000 SF of office space, 10,000 SF of lab space, and 10,000 SF of cleanroom space. The project was originally managed by a large construction management (CM) firm before CleanSpace took over, implementing a more efficient design-build approach.

Project Hightlights

  • Transitioned from a design-bid-build model to a design-build strategy, aligning user quality requirements with budget constraints.
  • Achieved 25% cost reduction through value engineering, eliminating MEP system redundancies.
  • Delivered Certificate of Occupancy (CO) in just 11 months, outperforming the original CM firm's 16-month schedule.
  • The project included all design aspects, ensuring a seamless turnkey solution fully owned by CleanSpace.
College Station, TX; Bellingham, UK

Major CDMO Client

Square Footage

25,000

Special details

A global CDMO in pharmaceutical manufacturing providing process development and cGMP production in cell culture, microbial fermentation, and gene therapies.

Project Hightlights

Texas site will become the largest single-use CDMO campus in North America.